The results from this research demonstrate that leadership involvement is the most important critical success factor that strongly and significantly correlates with institutionalization of MIS in these NAROs. Other factors such as adoption, adaptation, government support, ICT Infrastructure, organizational structure and culture, and transparency in information sharing also contribute to the success of institutionalization. The major critical failure factors that frustrate institutionalization are lack of funds for institutionalizing MIS, user resistance to change and lack of MIS policy/strategy guidelines. The Zambian and Ugandan NAROs can serve as benchmarks of good practices to other NAROs in Sub Saharan Africa wishing to introduce MIS in research management.