Drs. M.J. Jonker : Joint toxic effects on Caenorhabditis elegans

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2 May 2003 13:30
Unit: Wageningen University
Location: Aula (gebouw 362), Gen. Foulkesweg 1, Wageningen
Promotor: prof.dr.ir. J. Bakker (Nematology - Physiology and Molecular Ecology of Nematodes)
Co Promotor: dr.ir. J.E. Kammenga

 In this thesis ecotoxicological consequences of combination toxicity for the nematode Caenorhabditis elegans were investigated. A quantitative description procedure was proposed for analysing the toxicity of chemical mixtures compared to the toxicity of the individual components, based on maximum likelihood theory. Using these models, chronic exposure of binary mixtures of cadmium-copper and carbendazim-copper on the life history of C. elegans were studied. It was concluded that combined effects can be transient and can differ among life history traits. The observed synergistic effects on a relatively sensitive trait, reproduction, influenced the population growth rate. Finally, single and combined effects of copper-zinc, copper-cadmium, cadmium-lead, copper-carbendazim and copper-carbendazim-iprodion, on the one-week population increase in soil, in relation to soil sorption were studied. Synergism was detected at higher effect levels. However, comparing soil sorption characteristics to joint toxicity patterns did not reveal generic relationships. The predictability of combination toxicity is limited due to the condition specificity of the mixture effect.
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