Ir. E. van Zessen : Hydrodynamics of a liquid-liquid-solid fluidized bed bioreactor

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1 Oct 2003 13:30
Unit: Wageningen University
Location: Aula (gebouw 362), Gen. Foulkesweg 1, Wageningen
Promotor: prof.dr.ir. J. Tramper (Bioprocess Engineering)
Co Promotor: dr.ir. H.H. Beeftink en dr.ir. A. Rinzema

 If a batchwise bioconversion and subsequent (i.e. serial) downstream processing are adopted as a standard production strategy, a low overall productivity may result for certain types of biotransformations. An alternative to sequential processing would be the integration of bioconversion and downstream processing, with which a higger productivity would be attained. Such integration involves a multi-phase reactor in which a helper phase may serve as substrate reservoir (substrate-inhibited bioconversions) or as product sink (product-inhibited bioconversions). A new type of multi-phase bioreactor was developed, containing a continuous liquid phase, a dispersed liquid phase, and a dispersed solid phase; it may be conceived of as a 3-phase liquid-liquid-solid fluidized bed. This thesis focuses on and studies the hydrodynamic aspects of such a 3-phase fluidized bed; a general design strategy was developed.
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