Mw.drs. Y.E.M. Dommels : Effects of polyunsaturated fatty acids on colorectal carcinogenesis

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12 Sep 2003 16:00
Unit: Wageningen University
Location: Aula (gebouw 362), Gen. Foulkesweg 1, Wageningen
Promotor: prof.dr. P.J. van Bladeren (Toxico-kinetics and Biotransformation)
Co Promotor: dr. G.M. Alink, dr. B. van Ommen (TNO Voeding)

 High fat fish oil (HFFO) diets with a high amount of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA; 20:5n-3) inhibit the initiation of aberrant crypt foci (precursor lesions of colon cancer) in F344 rats compared to high fat corn oil diets with a high amount of n-6 PUFAs such as linoleic acid (LA; 18:2n-6). EPA also inhibits the proliferation of human adenocarcinoma Caco-2 cells compared to LA. The colon cancer inhibiting effects of n-3 PUFAs seems to be related to increased oxidative stress, because levels of lipid peroxidation as well as transcription of genes involved in oxidative stress are increased in HFFO fed rats. Furthermore, addition of antioxidants diminishes the anticancer effects of n-3 PUFAs in Caco-2 cells. Diets enriched with high levels of n-3 PUFAs may thus have beneficial colon cancer inhibiting effects, which may be reduced by high levels of dietary antioxidants.
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