M.F.M. Engel : Detailed Characterization of Adsorption-Induced Protein Unfolding

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7 Apr 2004 13:30
Unit: Wageningen University
Location: Aula (gebouw 362), Gen. Foulkesweg 1, Wageningen
Promotor: prof.dr. S.C. de Vries (Biochemistry (Molecular Enzymology))prof.dr. A.J.W.G. Visser (Biochemistry, VU)
Co Promotor: dr. C.P.M. van Mierlo

 Protein molecules stick to all kinds of surfaces, for example to medical implants and to contact lenses. To understand and rationally manipulate protein adsorption, knowledge of adsorption-induced changes in protein shapes is essential. In this thesis, the shape of a milk protein adsorbed on small plastic spheres is characterized in detail. The majority of the adsorbed protein molecules turn out to be in a state typical for a species that is observed during folding of the protein to its native shape. Protein adsorption is a novel approach to probe features of the shapes unfolding proteins can have.
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