Mw. Maria Zofia Siwek : Different genetic bases of immune responses in laying hens

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8 Mar 2005 16:00
Unit: Wageningen University
Location: Aula (gebouw 362), Gen. Foulkesweg 1, Wageningen
Promotor: prof.dr.ir. J.A.M van Arendonk (Animal Breeding and Genetics)
Co Promotor: dr. J.J. van der Poel, dr.ir. H.K. Parmentier

 The aim of the work described in this thesis is to identify genetic factors underlying immune response in laying hens.
In general, the unique QTL region related with immune responses to all the antigens under the study (SRBC, KLH, E.coli, M.butyricum) was not found. Furthermore, based on the results differences in the genetic regulation of antibody responses to two different T-cell dependent antigens, KLH and M. butyricum were suggested. The genetic components of innate immune responses were identified and relations between the innate and the adaptive immune system were described. The QTL results indicate that different regions are associated with levels of natural antibodies in poultry and that different genetic regions are involved in innate (non specific) and adaptive (specific) immune responses.
The QTL region detected for primary antibody response to KLH on GGA14 was fine mapped. This analysis resulted in narrowing down QTL region from initial 50cM to the region below 1cM.
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