Ms ir. M.E. Schutte: "The effect of flavonoids on the absorption of the heterocyclic amine PhIP"

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19 Oct 2007 13:30
Unit: Wageningen University
Location: Aula, building 362, Gen. Foulkesweg 1, Wageningen
Organisation: Wageningen University
Promotor: prof.dr. I.M.C.M Rietjens (Toxicology)
Co Promotor: Prof.dr.ir. J.P. Groten (Promotor), Dr. G.M. Alink, Dr.ir. J.J.M. van de Sandt (TNO, Zeist)

 This thesis describes the effect of flavonoids on the absorption of the carcinogenic heterocyclic amine PhIP. Flavonoids are present in e.g. fruits and vegetables and may protect against cardiovascular diseases and cancer. PhIP is formed during the heat processing of meat and fish and may cause certain forms of cancer. Recent studies showed that flavonoids interact with transport proteins present in the intestinal cells, which protect against the absorption of heterocyclic amines including PhIP.
By using cultured intestinal cells the present study showed that several flavonoids increase the absorption of PhIP, by inhibiting the transport proteins. These results were confirmed in an animal experiment. This thesis shows that flavonoids and their mixtures increase the absorption and bioavailability of PhIP. In conclusion, the results with the flavonoids, as a pure compound, suggest that the effect of fruit and vegetables on the absorption of PhIP, as it is present in heat processed meat and fish, needs further investigation.

Title thesis: "Effect of (mixtures of) flavonoids on the in vitroand in vivo bioavailability of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP): a biologically based modeling approach".
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