Mw.drs. J.C.M. (Jose) Aker: “Trafficking and endocytosis of BRI1 and SERK receptors”

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8 Oct 2008 13:30
Unit: Wageningen University
Location: Aula, building 362, Gen. Foulkesweg 1, Wageningen
Organisation: Wageningen University
Promotor: prof.dr. S.C. de Vries (Biochemistry (Molecular Enzymology))
Co Promotor: Dr. J.W. Borst

 To be able to react on environmental changes, plants use receptors on their cell membranes. Receptors in the plasma membrane catch signals via their extracellular domain and transduce these to other proteins. The receptors studied in this thesis are part of the brassinosteroid signaling pathway in Arabidopsis. The main receptor BRI1 binds brassinosteroids (BRs), upon which dimerization with the co-receptors SERK3 and SERK1 takes place. Receptors are removed from the plasma membrane to end up in small vesicles, the endosomes. From endosomes, either signaling or degradation of the receptors takes place.

The interaction between the SERK1 receptor and the CDC48A protein might be based on the mediation of degradation of mis-folded SERK1 proteins from the ER (endoplasmic reticulum) in the proteasome, in a quality control-like fashion. The co-receptors SERK1 and SERK3 are required for BR signaling, that takes place from the endosomes and not or less from BR signaling from the plasma membrane.
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