S. (Srdjan) Jovetic M.Sc: “Deacylation of glycopeptide antibiotic A40926 by immobilized Actinoplanes teichomyceticus cells – In quest of better drugs against MRSA”

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5 Jan 2010 16:00
Unit: Wageningen University
Location: Aula, building 362, Gen. Foulkesweg 1, Wageningen
Organisation: Wageningen University
Promotor: prof.dr.ir. J. Tramper (Bioprocess Engineering)
Co Promotor: Prof.dr. F. Marinelli (University of Insubria, Italy)

 A40926 is a natural glycopeptide antibiotic with a strong inhibitory activity against Gram-positive bacteria. By deacylation of A40926 an intermediate is produced that could be used for the synthesis of novel derivatives. These derivatives are defined as second-generation glycopeptides and are specifically designed  to be better drugs for the treatment of beta-lactam resistant Staphyloccous aureus and Staphylococcus epidermidis infections. In this thesis we studied and developed a lab-scale process for deacylation of A40926 using immobilized cells of Actinoplanes teichomyceticus.

Thesis title: Deacylation of glycopeptide antibiotic A40926 by immobilized Actinoplanes teichomyceticus cells - In quest of better drugs against MRSA
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