A.M. (Ana) Sotoca Covaleda, MSc: “Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds”

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14 Sep 2010 16:00
Unit: Wageningen University
Location: Aula, building 362, Gen. Foulkesweg 1, Wageningen
Organisation: Wageningen University
Promotor: prof.dr. I.M.C.M Rietjens (Toxicology)
Promotor: Prof.dr. A.J. Murk
Co Promotor: Dr.ir. J.J.M. Vervoort

 The multiple actions of estradiol and other estrogenic compounds in mammalian physiology are brought about, on a molecular level, as a result of complex signalling pathways, and mediated by at least two receptors namely estrogen receptor (ER) α and ERβ.

The aim of the work presented in this thesis was to obtain insight in the role of ERα, ERβ and the ratio of ERα/ERβ present within a cell, in the cellular response to estrogen-like compounds. To this end, this thesis addressed the transcriptional activity at both the gene and protein level and effects on cell proliferation under the influence of specifically-acting estrogen-like molecules when varying the ratio of ERα/ERβ present in the cells under study. The ultimate aim was to link the data on cell proliferation as the biological end-point to the transcriptomics and proteomics data.
Title thesis: “Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds”
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